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This observation reflects a severe permeability defect in the paracellular barrier mechanisms

A recent clinical study demonstrated that cognitively unimpaired individuals carrying the APOE 4 allele exhibited early BBB breakdown in the hippocampus and medial temporal lobe compared to non-carriers, with even greater BBB permeability observed in APOE 4 carriers who showed signs of cognitive impairment [122]

[The Working Group noted that an artificial sweetener mixture containing 54% aspartame (the other components being 23% cyclamate, 22% acesulfame-K, and 1% saccharin) was administered to the intervention diet group.] Bishop et al

Furthermore, it soothes and repairs the lining of the small intestine

Although marked spectral changes were detected in the hyperfine splitting constants of EBN/ SG upon its inclusion in CDs, resolved signals from the free and bound nitroxide were not obtained, and hence we did not assess the constants of the corresponding inclusion complexes